2,4-Dihydroxythieno[3,2-d]pyrimidine

2,4-Dihydroxythieno[3,2-d]pyrimidine - Names and Identifiers

Name	1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione
Synonyms	102776 hieno[3,2-d]pyrimidine-2,4-diol thieno[3,2-d]pyrimidine-2,4-diol Thieno[3,2-d]pyrimidine-2,4-diol 2,4-Dihydroxythieno[3,2-d]pyrimidine 1H-Thieno[3,2-d]pyrimidine-2,4-dione 1H-Thieno[3,2-d][1,3]oxazine-2,4-dione Thieno[3,2-d]pyrimidine2,4(1H,3H)-dione 1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione
CAS	16233-51-5
InChI	InChI=1/C6H2Cl2N2S/c7-5-4-3(1-2-11-4)9-6(8)10-5/h1-2H

2,4-Dihydroxythieno[3,2-d]pyrimidine - Physico-chemical Properties

Molecular Formula	C6H4N2O2S
Molar Mass	168.17
Density	1.517±0.06 g/cm3(Predicted)
Melting Point	>300 °C
Boling Point	274.804°C at 760 mmHg
Flash Point	119.997°C
Vapor Presure	0.009mmHg at 25°C
pKa	10.40±0.20(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	1.715
MDL	MFCD09909655

2,4-Dihydroxythieno[3,2-d]pyrimidine - Risk and Safety

Risk Codes	20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S24/25 - Avoid contact with skin and eyes. S36/37 - Wear suitable protective clothing and gloves.
HS Code	29335990

2,4-Dihydroxythieno[3,2-d]pyrimidine - Reference Information

application

1, 3-dihydrothiophene [3,2-D] pyrimidine -2, 4-dione is a pharmaceutical intermediate, which can be prepared by the reaction of methyl 3-aminothiophene-2-formate in urea. There are reports that it can be used to prepare PI3K inhibitors.

preparation

at room temperature, 47.0g(0.64mol) of urea is added to 250mL of eggplant bottle, and the temperature is raised to 140 ℃ to make urea in molten state, 20.0g(0.13mol) of methyl 3-aminothiophene-2-formate (a) was added in two batches under stirring, and then the temperature was raised to 190 ℃ for 2.5h. Cool the reaction solution to 120 ℃, add the reaction solution to 200mL of 20% sodium hydroxide aqueous solution while hot, stir until most of the solid is dissolved, filter by suction, filter out insoluble matter, adjust pH to 3 with 2M hydrochloric acid, filter by suction, and dry to obtain 18.5g of light yellow solid 1, 3-dihydrothiophene [3,2-D] pyrimidine -2, 4-dione with 86.4% yield.

Last Update：2024-04-10 22:29:15

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2,4-Dihydroxythieno[3,2-d]pyrimidine

2,4-Dihydroxythieno[3,2-d]pyrimidine

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione

CAS: 16233-51-5

Molecular Formula: C6H4N2O2S

2,4-Dihydroxythieno[3,2-d]pyrimidine - Names and Identifiers

2,4-Dihydroxythieno[3,2-d]pyrimidine - Physico-chemical Properties

2,4-Dihydroxythieno[3,2-d]pyrimidine - Risk and Safety

2,4-Dihydroxythieno[3,2-d]pyrimidine - Reference Information

Supplier List

2,4-Dihydroxythieno[3,2-d]pyrimidine Request for Quotation

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione

CAS: 16233-51-5

Molecular Formula: C6H4N2O2S

2,4-Dihydroxythieno[3,2-d]pyrimidine - Names and Identifiers

2,4-Dihydroxythieno[3,2-d]pyrimidine - Physico-chemical Properties

2,4-Dihydroxythieno[3,2-d]pyrimidine - Risk and Safety

2,4-Dihydroxythieno[3,2-d]pyrimidine - Reference Information

Supplier List

2,4-Dihydroxythieno[3,2-d]pyrimidine